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KMID : 1177320130160020093
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Korean Journal of Schizophrenia Research
2013 Volume.16 No. 2 p.93 ~ p.97
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Association between Antipsychotic-Related Restless Legs Syndrome and the RORA Gene Polymorphism in Schizophrenia
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Jung Jin-Sook
Cho Chul-Hyun
Yoon Ho-Kyoung
Kang Seung-Gul
Park Young-Min
Lee Heon-Jeong
Kim Leen
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Abstract
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Objectives: The previous studies have suggested genetic vulnerability to restless legs syndrome (RLS) development. The occurrence of antipsychotic-related RLS could also be attributable to differences in genetic susceptibility. This study aimed to investigate whether Retinoid-related orphan receptor A (RORA) gene polymorphism is associated with antipsychotic-related RLS in schizophrenia.
Methods: We assessed symptoms of antipsychotic-induced RLS in 190 Korean schizophrenic patients and divided the subjects into two groups according to the International Restless Legs Syndrome Study Group diagnostic criteria : 1) subjects that met all of the criteria (n=44) and 2) the remaining subjects who were not considered to be RLS patients (n=146). Single-nucleotide polymorphism in the RORA gene was genotyped by PCR in 190 individuals. The χ2-test was conducted to compare differences between two groups.
Results: The frequencies of genotype (χ2=0.066, p=0.968) of the RORA gene (rs11071547) did not differ significantly between schizophrenic patients with and without RLS. The difference of allele frequencies (χ2=0.008, p=0.927) of the RORA gene (rs 11071547) between the schizophrenic patients with and without RLS were not significant.
Conclusion: These results suggest that RORA gene polymorphism does not play a major role in susceptibility to antipsychotic-related RLS in schizophrenia.
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KEYWORD
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RLS, Schizophrenia, RORA, Genetic polymorphism, Circadian rhythm
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